NFL Betting: 2021 Regular Season Match - 49ers vs Eagles Preview

NFL Betting: 2021 Regular Season Match – 49ers vs Eagles Preview

Written by on September 16, 2021

Two teams who had a great start to the season will square off in Week 2, as the Philadelphia Eagles will host the San Francisco 49ers on Sunday at FedEx Field. Both of these teams showed off their offensive power last week. The Niners held off a late Lions comeback and defeated Detroit 41-33. The Eagles blew out the Atlanta Falcons 32-6. It’s time we take a closer look at the upcoming match between San Francisco 49ers vs Philadelphia Eagles so you can place your bets against the NFL odds.

San Francisco 49ers vs Philadelphia Eagles Betting Analysis

San Francisco 49ers

In his time in San Francisco, Jimmy Garoppolo has drawn the ire of many Niners fans. Even though he’s not flashy, he just wins games. In his 31 career starts as a San Francisco 49er, he boasts a 23-8 record. Although San Francisco drafted Trey Lance in the first round, this is Garoppolo’s team for now. Last week he threw for 314 yards with one touchdown in the Niners victory.

Garoppolo will lead the offense into Philadelphia, ready to put up more points. Deebo Samuel had a great game, George Kittle will be ready to break out, and rookie running back Elijah Mitchell had a phenomenal game after Raheem Mostert left with an injury. Mostert will be out for an extended amount of time, so we should see a lot more of Mitchell and fellow rookie Trey Sermon.

Even though they gave up 33 points last week, many of them were late in the game when it was basically decided; the Niners’ defense should be one of the best units in the league this season. With Nick Bosa leading a potent pass rush, the Eagles’ offensive line will have their work cut out for them this week.

Philadelphia Eagles

Philadelphia traveled to Atlanta and thoroughly dominated the Falcons in Week 1. Jalen Hurts had been challenged in camp by Joe Flacco and the newly acquired Gardner Minshew, but he ended up winning the starting job. He showed everyone why he was the best man for the job, as he went 27-35 for 264 yards with three touchdowns. Miles Sanders ran the ball well, and first-round pick DeVonta Smith had six catches for 71 yards with a touchdown.

Philadelphia’s defense stepped up to the challenge of stopping Matt Ryan, Calvin Ridley, Kyle Pitts, and the Falcons offense. In holding the Falcons to just six points, the Eagles’ defense looked impressive. We’ll see if they can repeat their effort against the Niners.


The Eagles are home underdogs this week as the San Francisco 49ers are 3.5 point favorites. Many saw the Eagles as the third-best team in the NFC East this year, but after their dominating performance in Week 1, people are rethinking their evaluations of the Eagles. 

While the Eagles are 4-0 against the spread in their last four home games, the Niners are 3-7 against the spread in their last ten games. The numbers suggest that the Eagles have the advantage, but we’re not quite ready to side with the numbers in this one.

The Eagles put up a lot of points against a porous Falcons defense. The Niners’ defense is a much better unit than the one the Eagles faced last week. With that being said, we give the advantage to the Niners in this one and have them winning by a touchdown, thus covering the spread.