NFL Betting: 2021 Season - Indianapolis Colts at San Francisco Match Preview

NFL Betting: 2021 Season – Indianapolis Colts at San Francisco Match Preview

Written by on October 22, 2021

When the NFL sets the Sunday Night Football schedule, they try their best to match up two teams that are playoff contenders. When they announced that the San Francisco 49ers would be hosting the Indianapolis Colts in the Week 7 primetime game, many felt that these two teams would be in playoff contention. We know that it’s early, but neither team looks like a playoff team right now. The Colts are 2-4 on the season, while the Niners are 2-3. This one will be huge for both teams, as the loser falls even deeper into an already deep hole. With that in mind, let’s check out our NFL Betting analysis for the upcoming matchup between the Indianapolis Colts versus the San Francisco 49ers.

Indianapolis Colts vs San Francisco 49ers Betting Analysis

San Francisco 49ers Betting Preview

The Niners have been hit hard by injuries this season. They’ve been through a plethora of running backs, and quarterback Jimmy Garoppolo has missed significant time this season. Rookie first-round pick Trey Lance has gotten some much-needed experience, but he has looked like a rookie quarterback. 

Although Kyle Shanahan has yet to announce his starter for Sunday, many think that we’ll see the return of Garoppolo under center. Something needs to spark the San Francisco offense, as they’re one of the lowest-scoring teams in the league. Without George Kittle, the Niners’ offense will need Deebo Samuel to continue to play well, and a spark from whichever running back he chooses to put in.

Defensively, the Niners have played well. They held the undefeated Arizona offense to just 17 points. Even though the Niners’ defense has had its fair share of injuries as well, they have held their own. They’ve only given up 119 points on the season. Fred Warner, Nick Bosa, and Dee Ford have led the charge on the defensive side of the ball.

Indianapolis Colts Betting Preview

The Colts are coming off of a 31-3 thrashing of the Houston Texans. While he got off to a slow start this season, quarterback Carson Wentz has picked things up recently. He has thrown for over 1500 yards with nine touchdowns and just one interception. Jonathan Taylor has turned it up over the last few weeks. He has rushed for nearly 500 yards with four touchdowns. With the return of TY Hilton, the Colts’ offense is starting to click. 

The Colts defense hasn’t played as well as it did last season. They’ll need to step things up if the Colts want to get back to the playoffs, as we just don’t have a lot of faith in Carson Wentz being able to win shootouts.


It’s hard to believe that the 49ers, who are on a four-game losing streak, are 4.5 point favorites in this one. We know they are at home, but we still don’t see how they’re the favorite. In looking at the numbers, they favor the Colts. Indianapolis is 7-2 against the spread in its last nine road games and 4-1 against the spread in its last five.

While the numbers look good for the Colts, they’re not so favorable for the Niners. San Francisco is 5-22-1 in its last 28 games as a favorite. They’re also 1-5 against the spread in their last six.

We are going to go with the numbers and pick the Colts. While we think San Francisco could win the game, we can’t see them covering.