NFL Betting: Cardinals V. 49ers Analysis

Posted by Derrick Harper on September 10, 2020 in

Late last season, the San Francisco 49ers looked like the best team in football. With their stellar running game and the top defense in the NFL, they looked like the team to beat.  After blowing a late lead to the Kansas City Chiefs in the Super Bowl, the 49ers are looking to show everyone that they’re ready to return to the Super Bowl this season. Let’s take a closer look at this upcoming match so you can bet against their NFL odds.

NFL: Arizona Cardinals at San Francisco 49ers Betting Preview

The 49ers will start their Super Bowl quest on Sunday afternoon as they host the Arizona Cardinals at Levi’s Stadium in Santa Clara. This game will be fun to watch, as Cardinals coach Kliff Kingsbury’s high-powered offense will square off against one of the top defenses in the NFL. 

San Francisco returns 20 of the 24 starters from last year’s Super Bowl team. After flirting with the idea of signing Tom Brady, the 49ers decided to keep incumbent Jimmy Garoppolo to lead the offense. 

The 49ers will have one of the top offensive lines in the league to protect Garoppolo and clear a path for running backs Raheem Mostert and Tevin Coleman. Trent Williams, a former All-Pro, will replace the retired Joe Staley, and Tom Compton will replace Mike Person, to help solidify the formidable offensive line. George Kittle, one of the top tight ends in football, will lead the 49ers receiving attack.

Injuries may hinder the Niners offense to start the season. Starting center Weston Richburg will miss time, as will starting receiver Deebo Samuel. Rookie Brandon Aiyuk, who was slated to replace Samuel, could miss some time as well.

As for the 49ers defense, this group should be just as menacing as they were last season. Other than losing DeForest Buckner in a trade to Indianapolis, the 49ers return the core of their 2019 defense. New defensive coordinator Tony Oden will have a lot of weapons at his disposal.

The Cardinals will have a very explosive offense. Kingsbury has put together a high-octane offense led by second-year signal-caller Kyler Murray. Murray is a dual-threat quarterback with numerous weapons at his disposal. 

Newly acquired star receiver DeAndre Hopkins, Larry Fitzgerald, and Christian Kirk lead the passing attack. Kenyan Drake and Chase Edmonds will give Arizona a superb ground game. The offensive line should be solid.

Defensively, the Cardinals struggled in 2019. However, they have made numerous free-agent acquisitions to accompany Chandler Jones, Budda Baker and first-round pick Isaiah Simmons. 

Patrick Peterson is healthy and is looking to bounce back from a sub-par 2019 season. If the Cardinals want to make a playoff run, they will need their defense to be vastly improved.

For Sunday’s matchup, the 49ers are seven-point favorites, and the over/under is 47.5. In their last five games against the 49ers, the Cardinals are 4-0-1 against the spread. 

San Francisco averaged nearly 30 points per game last season, while the Cardinals were just under 23.

We like the Cardinals getting the points on Sunday. In their last 11 games, San Francisco and their opponents have hit the over in eight of them. We think that it will be nine out of 12 after Sunday’s contest.